- Case of the week is a mother who becomes paralysed and then goes blind
- She swears that she and her daughter are always completely honest with each other; However her daughter was adopted
- Turns out the mom has breast cancer on the back of her knee
- House examines a prostitute in the clinic who got a rash from a donkey
- House goes to a church to see her as the Virgin Mary in a Nativity play
- House sabotages the team's Secret Santa thing so that everyone gets him a present